Cartoon: Bridging the gap between advances in biology and their application to major human diseases

Demystifying Medicine 2016

Tuesdays: January 5 through May 17
4:00pm - 6:00pm
Building 50 Conference Room
(unless otherwise noted)

Main Page - Return to 2018 Schedule
Course Materials
Speaker Profiles
Topic Introductions
Final Examination - Deadline May 25, 2016

Course Materials

January 5 - The Age of Insight: The Quest to Understand the Unconscious in Art, Mind and Brain from Vienna 1900 to the Present


January 12 - Ebola, MERS and Likelihood of More Epidemics & Evolutionary Dynamics and Zoonotic and Cross-Species Transmission of Emerging Viruses

Presentations:
- Anthony Fauci, MD (NIAID)
- Vincent Munster, PhD (NIAID)

Readings:
- Ending the HIV-AIDS Pandemic - Follow the Science
- Emerging Viral Diseases: Confronting Threats with New Technologies
- Ebola - Underscoring the Global Disparities in Health Care Resources
- Emerging Infectious Diseases: Threats to Human Health and Global Stability
- WHO/CDC Fact Sheets: Chikungunya, Dengue, Ebola, MERS, Zika
- The Merits of Malaria Diagnostics during an Ebola Virus Disease Outbreak
- Mutation rate and genotype variation of Ebola virus from Mali case sequences
- Understanding Ebola Virus Transmission
- Molecular Evidence of Sexual Transmission of Ebola Virus

January 19 - The Future of Medicine: Personalized, Precision and Other & The Future of Medicine: Intramural Research Plans

Presentation:
- Eric Green, MD PhD (NHGRI)

Readings:
- The Body Electric: Researchers want to Wire the Human Body with Sensors that could Harvest Reams of Data - and Transform Health Care
- A New Initiative on Precision Medicine
- Charting a Course for Genomic Medicine from Base Pairs to Bedside
- Twenty-Five Years of Big Biology

January 26 - Canceled Due to Weather - Rescheduled to May 17


February 2 - Where Do Viruses Come From and How Do They Do What They Do? & From A to E: 2000 Years of Hepatitis Virus History

Presentations:
- John Coffin, PhD (NCI/Tufts University)
- Harvey Alter, MD (CC)

Readings:
- Effects of Retroviruses on Host Genome Function
- The Origin of Viruses

February 9 - The Intestinal Microbiome and Inflammatory Bowel Disease

Presentations:
- Yasmine Belkaid, PhD (NIAID)
- Warren Strober, MD (NIAID)

Readings:
- Role of the Microbiota in Immunity and Inflammation
- Targeting the Microbiome in Inflammatory Bowel Disease: Critical Evaluation of Current Concepts and Moving to New Horizons
- NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6
- NOD2, an Intracellular Innate Immune Sensor Involved in Host Defense and Crohn's Disease
- Impact of the gut microbiome on mucosal inflammation
- Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohn's disease

February 16 - Atopy: The Common and The Rare Allergies in the Genomic Era

Presentations:
- Joshua Milner, MD (NIAID)
- Pamela Guerrerio, MD PhD (NIAID)

Readings:
- Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy
- Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis
- Early infancy microbial and metabolic alterations affect risk of childhood asthma

February 23 - "Shingles" (Herpes Zoster) Revisited

Presentations:
- Herpes Zoster by Lesia Dropulic, MD (NAID) and Jeffrey Cohen, MD (NIAID)
- Treatment and Prevention of Shingles by Lesia Dropulic, MD (NAID) and Jeffrey Cohen, MD (NIAID)

Readings:
- Herpes zoster
- Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP)
- Recommendations for the management of herpes zoster
- Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults.; ZOE-50 Study Group

March 1 - Cell Polarity: Mechanisms and Disease in the Nervous System and Liver

Presentations:
- Juan Bonifacino, PhD (NICHD)
- Irwin Arias, MD (CC/NICHD)

Readings:
- Structural and functional hepatocyte polarity and liver disease.
- LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes.
- Coordinated elevation of mitochondrial oxidative phosphorylation and autophagy help drive hepatocyte polarization.
- Hereditary Spastic Paraplegias: Membrane Traffic and the Motor Pathway
- Adaptor Proteins Involved in Polarized Sorting

March 8 - Depression: Neuromodulation Meets Super-Resolution Cell Biology

- Sarah H Lisanby, MD (NIMH)
- Justin Taraska, PhD (NHLBI)

March 15 - Non Alcoholic Fatty Liver Disease and Steato-Hepatitis (NAFLD/ NASH): An "Epidemic" Liver Disease Requiring New Drugs

Presentations:
- Yaron Rotman, MD (NIDDK)
- Rosana Kapellar, MD PhD (Nimbus)

Readings:
- Current efforts and trends in the treatment of NASH
- The Liver's Weighty Problem
- Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
- Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
- The Association of Genetic Variability in PNPLA3 with Histological Severity of Non-Alcoholic Fatty Liver Disease
- Human Fatty Liver Disease: Old Questions and New Insights
- Farnesoid X nuclear receptor ligand obeticholic acid for non- cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
- NASH is the 21st Century's Looming Public Health Threat
- Setting the Pace in the Race to Treat NASH
- From Crawl to Spring: The Race to Treat NASH

March 22 - Progress in Understanding Congenital Heart Disease (The #1 Killer in Birth Defects): Mechanisms and New Technologies

Presentations:
- Gail Pearson, MD (NHLBI)
- Robert Lederman, MD (NHLBI)

Readings:
- History
- Surgical ligation of a patent ductus arteriosus: report of first successful case
- The surgical treatment of malformations of the heart in which there is pulmonary stenosis or pulmonary atresia
- Percutaneous balloon valvulop0lasty: a new method for treating congenital pulmonary valve stenosis

- Epidemiology
- The incidence of congenital heart disease

- Genetics and cardiac development
- Genetic basis for congenital heart defects: current knowledge
- Making or breaking the heart: from lineage determination to morphogenesis
- De novo mutations in histone-modifying genes in congenital heart disease
- Congenital heart malformations induced by hemodynamic altering surgical interventions

- Fetal cardiology
- Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association

- Pediatric heart failure
- Heart failure in children, Part I: history, etiology, and pathophysiology
- Heart failure in children, Part II: diagnosis, treatment, and future directions

- Pediatric Heart Network trials
- Comparison of shunt types in the Norwood procedure for single-ventricle lesions
- Enalapril in infants with single ventricle: results of a multicenter randomized trial

- Adult congenital heart disease
- Adult congenital heart disease: a growing epidemic

- Three-dimensional printing
- Three-dimensional printing of intracardiac defects from three-dimensional echocardiographic images: feasibility and relative accuracy
- Echocardiography and three-dimensional printing: sound ideas to touch a heart
- "Just-in-time" simulation training using 3-D printed cardiac models after congenital cardiac surgery. Olivieri LJ, Su L, Hynes CF et al, World J Pediatr Congenit Heart Surg 2016;7:164-168.

- Additional Readings:
- MRI catheterization in cardiopulmonary disease
- Real-time MRI-guided right heart catheterization in adults using passive catheters
- Caval-aortic access to allow transcatheter aortic valve replacement in patients otherwise ineligible: Initial human experience
- Mitral cerclage annuloplasty, a novel transcatheter treatment for secondary mitral valve regurgitation: Initial results in swine
- Trans-atrial intra-pericardial tricuspid annuloplasty
- Transcatheter myocardial needle chemoablation during real-time MRI interactively depicts irreversible necrosis [In Press], Rogers T, Mahapatra S, Kim S, Eckhaus MA, Schenke WH, Mazal JR, Campbell-Washburn A, Sonmez M, Faranesh AZ, Ratnayaka K, Lederman RJ, Circulation Arrhythmia and Electrophysiology, 2016. (PMID pending; PMCID pending)

March 29 - The Oral Microbiome Meets Cell Biology and Periodontal Disease

Presentations:
- Presentations Combined
- Niki Moutsopoulos (NIDCR)
- Robert Palmer, PhD (NIDCR)
- Alex Valm, PhD (NICHD)

Readings:
- Periodontitis: from microbial immune subversion to systemic inflammation
- Defective neutrophil recruitment in Leukocyte Adhesion Deficiency Type I disease causes local IL-17-driven inflammatory bone loss
- Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing
- Biogeography of a human oral microbiome at the micron scale. Mark Welch, et al. 2015. PNAS 113:E791-800.

April 5 - Multiple Sclerosis: Mechanisms and Imaging the Process

Presentations:
- Combined Presentation File
- Daniel Reich, MD PhD (NINDS)
- Irene Cortese, MD (NINDS)

Readings:
- Spring cleaning: time to rethink imaging research lines in MS?
- MRI in Diagnosis and Disease Monitoring

April 12 - Global Warming: Effect on Vector Distribution, Disease and Natural Product Research

Presentations:
- Jonathan Sleeman, PhD (USGS)
- David Newman, PhD (NCI)

Readings:
- An environmental bacterial taxon with a large and distinct metabolic repertoire
- Natural Product-Derived Drugs Based on beta-Adrenergic Agents and Nucleosides

April 19 - Trauma in the Modern Age: Injury and Stem Cells

- Paul Pasquina, MD Colonel, (US Army USUHS)
- Ronald Mckay, PhD (Leiber Institute/Johns Hopkins)

April 26 - Hepatocellular Cancer: Problems and Progress in an Epidemic Disease

Presentations:
- Snorri Thorgeirsson, PhD (NCI)
- Tim Gretin MD (NCI)

May 3 - Cholesterol: Too Much and Too Little are Bad for Your Health

Presentations:
- Forbes Porter, MD, PhD (NICHD)
- Robert Shamburek, MD (NHLBI)

Readings:
- Modeling Smith-Lemli-Opitz syndrome with induced pluripotent stem cells reveals a causal role for Wnt/beta-catenin defects in neuronal cholesterol synthesis phenotypes
- Malformation syndromes caused by disorders of cholesterol synthesis
- Linear Clinical Progression, Independent of Age of Onset, in Niemann-Pick Disease, Type C
- The Online Metabolic and Molecular Bases of Inherited Disease. David Valle, Editor-in-Chief, Arthur L. Beaudet, Editor, Bert Vogelstein, Editor, Kenneth W. Kinzler, Editor, Stylianos E. Antonarakis, Editor, Andrea Ballabio, Editor, K. Michael Gibson, FACMG, Editor, Grant Mitchell, Editor.
- Familial Lecithin:Cholesterol Acyltransferase Deficiency: First-in-Human Treatment with Enzyme Replacement
- Safety and Tolerability of ACP-501, a Recombinant Human Lecithin: Cholesterol Acyltransferase, in a Phase 1 Single-Dose Escalation Study

May 10 - Robotic Planetary Exploration and Thoughts about Human Spaceflight

- Stamatios Krimigis , PhD (Johns Hopkins Applied Physics Laboratory)

May 17 - How Long Can and Should We Live? & What Centenurians Teach Us about Aging

Presentations:
- Luigi Ferrucci, MD (NIA): How Long Can and Should We Live?
- Nir Barzilai, MD (Albert Einstein College of Medicine): What Centenurians Teach Us about Aging

Readings:
- Functionally significant insulin-like growth factor-I receptors mutations in centenarians
- Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
- Disease variants in genomes of 44 centenarians
- Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia
- Age-Related Change in Mobility: Perspectives From Life Course Epidemiology and Geroscience
- Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
- Primary Prevention of Cardiovascular Disease with a Mediterranean Diet

 

For questions about the course, please contact ariasi@mail.nih.gov.
This web page was last modified on 15 September 2017.