Cartoon: Bridging the gap between advances in biology and their application to major human diseases

Demystifying Medicine 2018

Tuesdays: January 9 through May 8
4:00pm - 6:00pm
Building 50 Conference Room
(unless otherwise noted)

Main Page
Course Materials
Speaker Profiles
Topic Introductions
Final Examination

Course Materials

January 9 - New Viral Diseases, Universal Vaccines, and Removing Agents from the Blood Supply
Videocast

Presentations:
~ Anthony S. Fauci, MD (NIAID)
~ Robert Allison, MD, PHD (CC)

Readings:
~ Zika Virus in the Americas - Yet Another Arbovirus Threat
~ Safety and clinical efficacy of platelet components prepared with pathogen inactivation in routine use for thrombocytopenic patients
~ Emerging infectious disease agents and their potential threat to transfusion safety


January 16 - Is Childhood Leukemia Curable? Challenges and Milestones in Current Approaches
Videocast

Presentations:
~ Nirali Shah, MD, MHSc (NCI)
~ Haneen Shalabi, DO (NCI)B

Readings:
~ T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
~ CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy


January 23 - Sexually Transmitted Diseases: Situation Getting Worse...and Also Better
Videocast

Presentations:
~ Thomas Quinn, MD (NIAID/Johns Hopkins Bloomberg School of Public Health
~ Douglas Lowy, MD (NCI)

Readings:
~ Sexually Transmitted Disease Surveillance 2016
~ Sexually transmitted infections: challenges ahead
~ Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines, 2015
~ A cluster of ocular syphilis cases-Seattle, Washington, and San Francisco, California, 2014-2015
~ CDC. Clinical advisory: ocular syphilis in the United States 2015
~ Ocular Syphilis - Eight Jurisdictions, United States, 2014-2015
~ Neisseria gonorrhoeae Antimicrobial Susceptibility Surveillance - The Gonococcal Isolate Surveillance Project, 27 Sites, United States, 2014. MMWR Surveill Summ 2016;65(No. SS-7):1-19.
~ Prevalence of Pelvic Inflammatory Disease in Sexually Experienced Women of Reproductive Age - United States, 2013-2014.
~ M Unemo, JS Jensen Antimicrobial-resistant sexually transmitted infections: gonorrhoea and Mycoplasma genitalium Nat Rev Urol, 14 (2017), pp. 139-152
~ Global estimates of the prevalence and incidence of four curable sexually transmitted infections in 2012 based on systematic review and global reporting.
~ Chen X-S. Challenges in responses to syphilis epidemic. Lancet Infect Dis 2017; published online July 9. http://dx.doi.org/10.1016/S1473 - 3099(17)30327-4.


January 30 - Why is HIV Still a Biologic and Epidemiologic Challenge Worldwide?
Videocast

Presentations:
~ John Coffin, PhD (Tufts/NCI)
~ John Mellors, MD (University of Pittsburgh)


February 6 - The New Frontier: Immunotherapy of Cancer
Videocast

Presentations:
~ James Gulley, MD, PhD (NCI)
~ James Hodges, PhD, MBA (NCI)

Readings: ~ Avelumab for metastatic or locally advanced previously treated solid tumours (JAVELIN Solid Tumor): a phase 1a, multicohort, dose-escalation trial
~ (R)Evolutionary Therapy: The Potential of Immunotherapy to Ful ll the Promise of Personalized Cancer Treatment
~ Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death
~ Immune Impact Induced by PROSTVAC (PSA-TRICOM), a Therapeutic Vaccine for Prostate Cancer
~ Attacking malignant cells that survive therapy - Exploiting immunogenic modulation
~ Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing


February 13 - Does Inflammation Cause Cardiovascular Disease? If So, How?
Videocast

Presentations:
~ Alan Remaley, MD, PhD (NHLBI)
~ Nehal Mehta, MD (NHLBI)


February 20 - The Microbiome in Man, Animals, and Disease: Where Do We Stand?
Videocast

Presentations:
~ Yasmine Belkaid, PhD (NIAID)
~ Barbara Rehermann, MD (NIDDK)

Readings:
~ Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance
~ ImmuneResponses to HCV and Other Hepatitis Viruses
~ Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection


February 27 - The Great Neglected Diseases
Videocast

Presentations:
~ Alan Sher, PhD (NIAID)
~ Thomas Nutman, MD (NIAID)

Readings:
~ Eosinophil-Associated Processes Underlie Differences in Clinical Presentation of Loiasis Between Temporary Residents and Those Indigenous to Loa-Endemic Areas
~ Targeting Filarial Abl-like Kinases: Orally Available, Food and Drug Administration-Approved Tyrosine Kinase Inhibitors Are Microfilaricidal and Macrofilaricidal
~ A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa-Endemic Areas
~ Reduction of Loa loa Microfilaremia with Imatinib - A Case Report


March 6 - Diabetes and Artificial Sweeteners
Videocast

Presentations:
Phillip Gorden, MD (NIDDK)
Kristina Rother, MD (NIDDK)

Readings:
~ Partial and Generalized Lipodystrophy: Comparison of Baseline Characteristics and Response to Metreleptin
~ Treatment of Type B Insulin Resistance: A Novel Approach to Reduce Insulin Receptor Autoantibodies
~ Efficacy of Recombinant Methionyl Human Leptin Therapy for the Extreme Insulin Resistance of the Rabson-Mendenhall Syndrome


March 13 - Brave New World: Imaging from the Cosmos to the Molecule
Videocast

Presentations:
~ John Mather, PhD, (National Aeronautics and Space Administration)
~ Jennifer Lippincott-Schwartz, PhD, MS (HHMI, Janelia Research Campus)

Readings:
~ Applying systems-level spectral imaging and analysis to reveal the organelle interactome
~ Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER


March 20 - The Challenge of Malaria: The World's Number One Killer
Videocast:

Presentations:
~ Peter Crompton, MD, MPH (NIAID)
~ Photini Sinnis, MD, Johns Hopkins Bloomberg School of Public Health

Readings:
~ Malaria Vaccines and Human Immune Responses
~ Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition
~ First Results of a Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children
~ A controlled human malaria infection model enabling evaluation of transmission-blocking interventions Journal Clinical Investigation
~ Proteolytic Cleavage of the Plasmodium falciparum Circumsporozoite Protein Is a Target of Protective Antibodies


March 27 - Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease): Are We Making Progress?
Videocast:

Presentations:
~ Bryan Traynor MD, PhD, MMSc (NIA)
~ Mary Kay Floeter, MD, PhD (NINDS)

Readings:
~ Amyotrophic lateral sclerosis
~ State of play in amyotrophic lateral sclerosis genetics
~ Amyotrophic Lateral Sclerosis
~ Projected increase in amyotrophic lateral sclerosis from 2015 to 2040
~ Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications


April 3 - Compulsive Disorders: Mechanisms and Management
Videocast:

Presentations:
~ Antonello Bonci, MD (NIDA)
~ Veronica Alvarez, PhD (NIAAA)

Readings:
~ Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking
~ Illuminating next-generation brain therapies
~ Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaineuse: A pilot study


April 10 - Use of Stem Cells for Regenerative Medicine
Videocast:

Presentations:
~ Kapil Bharti, PhD (NEI)
~ Pamela Robey, PhD (NIDCR)

Readings:
~ Manufacturing Differences Affect Human Bone Marrow Stromal Cell Characteristics and Function: Comparison of Production Methods and Products from Multiple Centers
~ Skeletal stem cells
~ Cell Sources for Bone Regeneration: The Good, the Bad, and the Ugly (But Promising)


April 17 - The Opioid Epidemic: How, Where, and What Can Be Done?
Videocast:

Presentations:
~ Nora Volkow, MD PhD (NIDA)
~ Walter Koroshetz, MD (NINDS)

Readings:
~ A common neurobiology for pain and pleasure
~ Breaking barriers to novel analgesic drug development


April 24 - Prenatal Genomics and Fetal Gene Therapy
Videocast:

Presentations:
~ Diana Bianchi, MD (NICHD)
~ Alan De Cherney, MD (NICHD)

Readings:
~ Noninvasive Prenatal DNA Testing: The Vanguard of Genomic Medicine
~ Cherchez la femme: maternal incidental findings can explain discordant prenatal cell-free DNA sequencing results


May 1 - "Bridge Building," Careers for PhD and MD Fellows
Videocast:

Presentations:
~ Michael Gottesman, MD (OD/NCI)
~ Jonathan Yewdell, MD, PhD (NIAID)
~ Win Arias, MD (CC)

Readings:
~ Truth Wins: A Practical Guide to Succeeding in Biomedical Research
~ Science Sunday Talk on Scientific Method


May 8 - The National Institutes of Hope
Videocast:

Presentations:
~ Francis Collins, MD, PhD


 

For questions about the course, please contact ariasi@mail.nih.gov.
This web page was last modified on 30 May 2018.