Cartoon: Bridging the gap between advances in biology and their application to major human diseases

Demystifying Medicine 2019

Tuesdays: January 8 through May 7
4:00pm - 5:30pm
Building 50 / Conference Room 1227
(unless otherwise noted)

Main Page
Course Materials
Speaker Profiles
Topic Introductions
Final Examination - Deadline: Tuesday, May 28 at 6:00pm ET


Course Materials

January 8 - Emerging and Re-emerging Infectious Diseases: A Perpetual Challenge & The Next Influenza Pandemic
Videocast
Presentations:
~ Anthony S. Fauci, MD (NIAID)
~ Jeffery Taubenberger MD, PhD (NIAID)
Readings:
~ The Role of Viral, Host, and Secondary Bacterial Factors in Influenza Pathogenesis
~ Influenza Cataclysm, 1918
~ Pandemic Influenza Viruses - Hoping for the Road Not Taken
~ The Persistent Legacy of the 1918 Influenza Virus
~ Contemporary Avian Influenza A Virus Subtype H1, H6, H7, H10, and H15 Hemagglutinin Genes Encode a Mammalian Virulence Factor Similar to the 1918 Pandemic Virus H1 Hemagglutinin
~ An HIV Vaccine Is Essential for Ending the HIV/AIDS Pandemic
~ Ending the HIV-AIDS Pandemic - Follow the Science
~ HIV Preexposure Prophylaxis


January 15 - Sepsis and the NIH Critical Care Center
Videocast
Presentations:
~ Anthony Suffredini, MD (CC)
~ Robert Munford, MD (NIAID)
     * Presentation
     * Movie - Volunteer
     * Movie - Sepsis
Readings:
~ Severe Sepsis and Septic Shock: The Role of Gram-Negative Bacteremia
~ Normal Responses to Injury Prevent Systemic Inflammation and Can Be Immunosuppressive
~ Novel therapies for septic shock over the past 4 decades
~ Endotoxemia-menace, marker, or mistake?
~ Sepsis: a roadmap for future research
~ The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
~ The immunopathology of sepsis and potential therapeutic targets
~ Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data
~ Using objective clinical data to track progress on preventing and treating sepsis: CDC's new 'Adult Sepsis Event' surveillance strategy
~ Current Sepsis Mandates Are Overly Prescriptive, and Some Aspects May Be Harmful


January 22 - Tuberculosis: The Great White Plague Keeps Coming Back
Videocast
Presentations:
~ Clifton Barry, PhD (NIAID)
~ Ray Chen, MD, (NIAID)



January 29 - Fungus Infections: Neglected, Dangerous and Increasing
Videocast
Presentations:
~ Arturo Casadevall, MD, PhD (Johns Hopkins University)
~ Michail Lionakis MD, ScD (NIAID)
Readings:
~ Host Control of Fungal Infections: Lessons from Basic Studies and Human Cohorts


February 5 - Exploring Deep Sea Eco Systems and Human Disease
Videocast
Presentation
~ Stefan Sievert, PhD (Woods Hole Oceanographic Institution)
~ John Dekker, MD, PhD (NIAID)
Readings:
~ Metagenomics for Clinical Infectious Disease Diagnostics Steps Closer to Reality
~ Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates
~ Actionable Diagnosis of Neuroleptospirosis by Next-Generation Sequencing
~ Real-time, portable genome sequencing for Ebola surveillance
~ Primary productivity below the seafloor at deep-sea hot springs
~ Transcriptomic and proteomic insight into the mechanism of cyclooctasulfur- versus thiosulfate-oxidation by the chemolithoautotroph Sulfurimonas denitrificans
~ Bacterial diversity and successional patterns during biofilm formation on freshly exposed basalt surfaces at diffuse-flow deep-sea vents
~ Pan-genoome analyses identify lineage- and niche-specific markers of evolution and adaptation in Epsilonproteobacteria
~ Chemoautotrophy at Deep-Sea Vents
~ Beyond the Calvin Cycle: Autotrophic Carbon Fixation in the Ocean


February 12 - Hepatocellular Cancer: Progress in a Devastating Disease
Videocast
Presentation
~ Marc Ghany, MD (NIDDK)
~ Anuradha Budhu, PhD (NCI)
Readings:
~ Common Molecular Subtypes among Asian Hepatocellular Carcinoma and Cholangiocarcinoma
~ Integrated Metabolite and Gene Expression Profiles Identify Lipid Biomarkers Associated with Progression of Hepatocellular Carcinoma and Patient Outcomes
~ Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
~ Budhu, A., Ji, J. and Wang, X.W. Molecular profiling of human hepatocellular carcinoma. Hepatocellular carcinoma diagnosis and treatment, Third edtion. Editor: B. Carr. Publishers: Humana Press, NY. (Chapter 5) 93-112, 2016.
~ Hepatocellular carcinoma


February 19 - Mount Everest and K2: Too Little and Too Much Oxygen
Videocast
Presentation
~ Louis Reichardt, PhD (Simons Foundation)
~ Toren Finkel MD, PhD (University of Pittsburgh)
Readings:
~ The role of mitochondria in aging
~ Measuring In Vivo Mitophagy
~ Oxidants, oxidative stress and the biology of ageing
~ From Summit to SFARI: The High-Altitude Life of Louis F. Reichardt


February 26 - Cellular Immunotherapy of Cancer
Videocast
Presentations:
~ Steven Rosenberg, MD, PhD (NCI)
~ Nirali Shah, MD, MHSc (NCI)
Readings:
~ Adoptive cell transfer as personalized immunotherapy for human cancer
~ 'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations
~ Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer


March 5 - The Case for Reason, Science, Humanism, and Progress
Videocast
Presentation:
~ Steven Pinker, PhD (Harvard University)


March 12 - Machine Learning and Artificial Intelligence in Radiology
Videocast
Presentations:
~ Ronald Summers MD, PhD (CC)
~ Baris Turkbey MD (NCI)
Readings:
~ Prostate Cancer: Value of Multiparametric MR Imaging at 3 T for Detection-Histopathologic Correlation
~ Comparison ofMR/ultrasound fusion-guided biopsy with ultrasound-guided biopsy for the diagnosis of prostate cancer
~ A Magnetic Resonance Imaging-Based Prediction Model for Prostate Biopsy Risk Stratification
~ What Are We Missing? False-Negative Cancers at Multiparametric MR Imaging of the Prostate
~ Computer-aideddiagnosis prior to conventional interpretation of prostate mpMRI: an international multi-reader study
~ Deep learning in medical imaging and radiation therapy
~ Prostate Cancer Detection from Multi-institution Multiparametric MRIs using Deep Convolutional Neural Networks
~ Chest X-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases
     * IEEE CVPR 2017, pp. 2097-2106 (2017)
     * IEEE CVPR 2017, pp. 3462-3471
     * IEEE Conference on Computer Vision and Pattern Recognition
~ DeepLesion: Automated Mining of Large-Scale Lesion Annotations and Universal Lesion Detection with Deep Learning


March 19 - Inheritable Cancer
Videocast
Presentations:
~ Marston Linehan, MD (NCI)
~ Sharon Savage, MD (NCI)
Readings:
~ Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging AMeta-analysis
~ Risks of First and Subsequent Cancers Among TP53 Mutation Carriers in the National Cancer Institute Li-Fraumeni Syndrome Cohort
~ Inherited TP53 Mutations and the Li-Fraumeni Syndrome


March 26 - Losing and Regaining Hearing:  From Humans to Zebrafish
Videocast
Presentations:
~ Shawn Burgess, PhD (NHGRI)
~ Andrew Griffith MD, PhD (NIDCD)
Readings:
~ Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues
~ Using Zebrafish to Study Human Deafness and Hearing Regeneration
~ Extracellular HSP60 triggers tissue regeneration and wound healing by regulating inflammation and cell proliferation


April 2 - Perception and Mis-perception in the Nervous System
Videocast
Presentations:
~ Nadia Biassou, MD, PhD (CC)
~ Marine Vernet, PhD (NIMH)
Readings:
~ How Art and Neuroscience Fell for Each Other
~ Frontal eye field, where art thou? Anatomy, function, and non-invasive manipulation of frontal regions involved in eye movements and associated cognitive operations
~ Synchronous and opposite roles of the parietal and prefrontal cortices in bistable perception: a double-coil TMS-EEG study
~ Endogenous visuospatial attention increases visual awareness independent of visual discrimination sensitivity
~ ECoG gamma activity during a language task: differentiating expressive and receptive speech areas
~ Thymic epithelial tumors and metastasis to the brain: a case series and systematic review
~ Improving the use of principal component analysis to reduce physiological noise and motion artifacts to increase the sensitivity of task-based fMRI
~ New cerebral findings in infants with congenital Zika syndrome


April 9 - Global Challenges in Infection: HIV Persists & Fungus Infections: Neglected, Dangerous, and Increasing
Videocast
Presentations:
~ John Coffin, PhD (NCI/Tufts University)
~ Arturo Casadevall, MD, PhD (Johns Hopkins University)


April 16 - Premature and Unusual Causes of Coronary Heart Disease
Videocast
Presentations:
~ Douglas Rosing, MD (NHLBI)
~ Manfred Boehm, MD (NHLBI)
Readings:
~ Coronary Atherosclerosis: Pathophysiologic Basis for Diagnosis and Management
~ The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction
~ Defining the Human Envirome: An Omics Approach for Assessing the Environmental Risk of Cardiovascular Disease


April 23 - Autoimmunity: Basic and Clinical Advances and Challenges
Videocast
Presentations:
~ Ronald Germain, MD, PhD (NIAID)
~ James Katz, MD (NIAMS)
Readings:
~ Histo-Cytometry: A Method for Highly Multiplex Quantitative Tissue Imaging Analysis Applied to Dendritic Cell Subset Microanatomy in Lymph Nodes
~ Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo
~ Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D)
~ A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System


April 30 - Dementias in the Genomic Era
Presentations:
~ Bryan Traynor, M.D., Ph.D. (NIA)
~ Sonja Scholz, M.D., Ph.D.(NINDS)


May 7 - Futures for PhDs
Videocast
Presentations:
~ Michael Gottesman, MD (DDIR, NIH)
~ Win Arias, MD (CC)
~ Sharon Milgram, PhD (OD)


 

For questions about the course, please contact ariasi@mail.nih.gov.
This web page was last modified on 19 April 2019.