Cartoon: Bridging the gap between advances in biology and their application to major human diseases

Demystifying Medicine 2019

Tuesdays: January 8 through May 7
4:00pm - 5:30pm
Building 50 / Conference Room 1227
(unless otherwise noted)

Main Page
Course Materials
Speaker Profiles
Topic Introductions
Final Examination


Speaker Profiles

January 8 - Emerging and Re-emerging Infectious Diseases: A Perpetual Challenge & The Next Influenza Pandemic
~ Anthony S. Fauci, MD (NIAID) - Anthony S. Fauci, M.D. is a physician-scientist who directs the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health in Bethesda, Maryland. He oversees an extensive research program on infectious diseases such as HIV/AIDS, influenza, tuberculosis, Ebola and Zika, as well as diseases of the immune system. Dr. Fauci also serves as one of the key advisors to the White House and Department of Health and Human Services on global infectious disease issues. He was one of the principal architects of the President's Emergency Plan for AIDS Relief (PEPFAR), a program that has saved millions of lives throughout the developing world. Dr. Fauci also is the long-time chief of the NIAID Laboratory of Immunoregulation where he has made numerous important discoveries related to HIV/AIDS and is one of the most-cited scientists in the field. He is a member of the US National Academy of Sciences and the US National Academy of Medicine and has received numerous prestigious awards for his scientific and global health accomplishments, including the National Medal of Science, the Robert Koch Medal, the Mary Woodard Lasker Award for Public Service, and the Presidential Medal of Freedom. He has been awarded 45 honorary doctoral degrees and is the author, coauthor, or editor of more than 1,300 scientific publications, including several major textbooks.

~ Jeffery Taubenberger MD, PhD (NIAID) - Jeffery K. Taubenberger, M.D., Ph.D., is Chief of the Viral Pathogenesis and Evolution Section, and Deputy Chief of the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases. Prior to coming to NIAID in 2006, he served as Chair of the Department of Molecular Pathology at the Armed Forces Institute of Pathology (AFIP) in Washington, DC, a position he held since 1994. He received a B.S. in Biology from George Mason University in 1982, his M.D. in 1986 and Ph.D. in 1987 from the Medical College of Virginia. He did his residency in pathology at the National Cancer Institute. He holds dual board certifications in Anatomic Pathology and in Molecular Genetic Pathology. Dr. Taubenberger's research interests include influenza virus biology, pathophysiology, clinical influenza research, and development of a universal influenza vaccine. Among his key contributions to the field was the sequence, reconstruction, and characterization of the virus responsible for the 1918 influenza pandemic, which killed approximately 50 million people worldwide. He is a recipient of numerous awards and a frequent speaker at national and international meetings He has published over 250 papers and book chapters. His research has generated national and international publicity since 1997.


January 15 - Sepsis and the NIH Critical Care Center
~ Anthony Suffredini, MD (CC) - Deputy Chief, Senior Investigator Critical Care Medicine Department, Clinical Center - Dr. Suffredini graduated from the University of Connecticut School of Medicine, completed a residency in Internal Medicine at the Medical College of Virginia and a fellowship in Critical Care Medicine at the University of Pittsburgh. He came to the Clinical Center in 1984 to pursue further training and research in critical care and became a senior investigator in 1989. His research has investigated different aspects of human inflammation as they relate to critical illness (i.e sepsis, septic shock, pulmonary inflammation). His presentation will describe a case that exemplifies the type of patient seen at the NIH Clinical Center who develops sepsis and septic shock. He will then discuss the diagnosis and therapy of these syndromes. Dr. Munford will complement this presentation with an overview of pathogenic mechanisms that underlie these disorders.

~ Robert Munford, MD (NIAID) - Senior Clinician, Laboratory of Clinical Immunology and Microbiology, NIAID. Dr. Munford came to NIH in 2009 after a long career at University of Texas Southwestern Medical School, Dallas, Texas, where his laboratory studied bacterial lipopolysaccharides (endotoxins) and discovered the animal enzyme that detoxifies them, acyloxyacyl hydrolase (AOAH). At NIH he has found that AOAH can inactivate not only endotoxins but also bacterial lipoproteins and the oxidized phospholipids that are produced by animals. He has also been studying how macrophages adapt to living in acidic fluid in order to survive. Today he will begin the session by giving a general overview of the pathogenesis of sepsis, the body's often lethal yet poorly understood response to infection.


January 22 - Tuberculosis: The Great White Plague Keeps Coming Back
~ Clifton Barry, PhD (NIAID) - Dr. Clifton E. Barry III received his Ph.D. in organic and bio-organic chemistry in 1989 from Cornell University, studying the biosynthesis of complex natural products. Following postdoctoral research at Johns Hopkins University, Dr. Barry joined the National Institute of Allergy and Infectious Diseases' (NIAID's) Rocky Mountain Laboratories. In 1998, he was tenured as chief of the Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, NIAID. The TRS is a multidisciplinary group of research scientists comprised of biologists, chemists and clinical researchers who share a common interest in TB. TRS projects focus on understanding the scientific issues that facilitate the development of drugs that will make a genuine difference in the outcome for TB patients globally. TRS scientists are highly interactive worldwide in this endeavor and as a result of our outstanding collaborations TRS is the most widely cited TB research group in the world. In addition to current TRS laboratories in Bethesda TRS works closely with the International Tuberculosis Research Center located in Masan, South Korea; with Chinese colleagues at the Henan Provincial Chest Hospital in Zhengzhou, China; and with colleagues at Stellenbosch University and the University of Cape Town in South Africa.

~ Ray Chen, MD, (NIAID) - Ray Chen is a staff clinician in the Tuberculosis Research Section (TRS) of the Laboratory of Clinical Infectious Diseases at the National Institute of Allergy and Infectious Diseases (NIAID), U.S. National Institutes of Health (NIH). Dr. Chen graduated from the Medical College of Virginia in Richmond, Virginia, then trained in Internal Medicine at the Thomas Jefferson University Hospital in Philadelphia, Pennsylvania and in Infectious Diseases at the University of Alabama at Birmingham (UAB). While at UAB, he also received a Masters of Science in Public Health with a concentration in epidemiology. He is certified by the American Board of Internal Medicine in Internal Medicine and Infectious Diseases. Dr. Chen has worked for NIH since 2003 and was based in Beijing, China from 2004-2012, where he administered the larger NIAID research projects in China, primarily in HIV, influenza, and tuberculosis. He worked with U.S. and Chinese investigators to develop clinical research infrastructure at research sites, conduct clinical trials to international standards, and analyze data and publish research results. Currently, Dr. Chen is the staff clinician in the Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, Division of Intramural Research at the NIAID. He leads the TRS clinical research team in conducting a number of clinical trials in South Korea, China, and South Africa on developing new treatment and diagnostic methods for drug-sensitive and drug-resistant tuberculosis. He has co-authored over 30 articles published in peer-reviewed journals.


January 29 - Fungus Infections: Neglected, Dangerous and Increasing
~ Arturo Casadevall, MD, PhD (Johns Hopkins University)
~ Michail Lionakis MD, ScD (NIAID)


February 5 - Exploring Deep Sea Eco Systems and Human Disease
~ Stefan Sievert, PhD (Woods Hole Oceanographic Institution)
~ John Dekker, MD, PhD (NIAID)


February 12 - Hepatocellular Cancer: Progress in a Devastating Disease
~ Marc Ghany, MD (NIDDK)
~ Anuradha Budhu, PhD (NCI)


February 19 - Mount Everest and K2: Too Little and Too Much Oxygen
~ Louis Reichardt, PhD (Simons Foundation)
~ Toren Finkel MD, PhD (University of Pittsburgh)


February 26 - Immunotherapy of Cancer
~ Steven Rosenberg, MD, PhD (NCI)
~ Nirali Shah, MD, MHSc (NCI)


March 5 - The Case for Reason, Science, Humanism, and Progress
~ Steven Pinker, PhD (Harvard University)


March 12 - Machine Learning and Artificial Intelligence in Radiology
~ Ronald Summers MD, PhD (CC)
~ Baris Turkbey MD (NCI)


March 19 - Inheritable Cancer
~ Marston Linehan, MD (NCI)
~ Sharon Savage, MD (NCI)


March 26 - Losing and Regaining Hearing:  From Humans to Zebrafish
~ Shawn Burgess, PhD (NHGRI)
~ Andrew Griffith MD, PhD (NIDCD)


April 2 - Perception and Mis-perception in the Nervous System
~ Nadia Biassou, MD, PhD (CC)
~ Marine Vernet, PhD (NIMH)


April 9 - Global Challenges in Infection with HIV and other Viruses
~ Roger Glass, MD, PhD (Fogarty International Center)
~ John Coffin, PhD (NCI/Tufts University)


April 16 - Premature and Unusual Causes of Coronary Heart Diseasen
~ Douglas Rosing, MD (NHLBI)
~ Manfred Boehm, MD (NHLBI)


April 23 - Autoimmunity: Basic and Clinical Advances and Challenges
~ Ronald Germain, MD, PhD (NIAID)
~ James Katz, MD (NIAMS)


May 7 - Futures for PhDs
~ Michael Gottesman, MD (DDIR, NIH)
~ Win Arias, MD (CC)
~ Sharon Milgram, PhD (OD)

 

This web page was last modified on 21 January 2019.
For questions about the course, please contact ariasi@mail.nih.gov.